2019

 

Matis DA, Zhang JM, Ouyang J, Nguyen HD, Genois MM, and Zou L. ATR Protects the Genome against R loops through a MUS81-Triggered Feedback Loop. Molecular Cell Oct 28. pii: S1097-2765(19)30770-1


Nguyen HD, Zou L, and Graubert TA. Targeting R-loop-associated ATR response in myelodysplastic syndrome. Oncotarget 10(27)2581-82

2018

 

Nguyen HD*, Leong WY*, Li W, Reddy PNG, Sullivan JD, Walter MJ, Zou L, and Graubert TA. Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibitor in Myelodysplastic Syndrome. Cancer Research, 78(18):5363-74. (*co-first author). 

Becker JR, Gallo D, Leung W, Croissant T, Thu YM, Nguyen HD, Starr TK, Brown GW, Bielinsky AK. Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner. Nucleic Acids Research. 46(11):5634-5650. 

Kabeche L, Nguyen HD, Buisson R, Zou L. A Mitosis-specific and R-loop driven ATR pathway promotes faithful chromosome segregation. Science. 359(6371):108-114. 

Nguyen HD and Zou L. Getting a Genomic View of DNA Replication Stress. Molecular Cell. Oct 18;72(2):201-203.

2017

 

Nguyen HD*, Yadav T*, Giri S, Saez B, Graubert TA, and Zou L. Functions of Replication Protein A as a Sensor of R Loop and a Regulator of RNaseH1. Molecular Cell.65(5):832-847. (*co-first author). 

Yazinski SA, Comaills V, Buisson R, Genois MM, Nguyen HD, Ho CK, Todorova Kwan T, Morris R, Lauffer S, Nussenzweig A, Ramaswamy S, Benes CH, Haber DA, Maheswaran S, Birrer MJ, Zou L. ATR Inhibitors Overcome the Resistance of BRCA1-Deficient Cancer Cells to PARP Inhibition. Genes & Development. 31(3):318-332. 

2016

 

Thu YM, Van Riper SK, Higgins L, Zhang T, Becker JR, Markowski TW, Nguyen HD, Griffin TJ, Bielinsky AK. Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression. Cell Reports 15(6):1254-65.

2015

 

Becker JR, Pons C, Nguyen HD, Costanzo M, Boone C, Myers CL, Bielinsky AK. Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing. PLoS Genetics. 11(11):e1005659 

Ouyang J, Garner E, Hallet A, Nguyen HD, Richman KA, Gill G, Smogorzewska A, and Zou L. Non-covalent interactions with SUMO and Ubiquitin orchestrate distinct functions of the SLX4 complex in DNA repair. Molecular Cell. 57(1):108-22. 

2014

 

Wu CS, Ouyang J, Mori E, Nguyen HD, Maréchal A, Hallet A, Chen DJ, and Zou L. SUMOylation of ATRIP potentiate DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Genes & Development. 28(13):1472-84. 

Becker JR, Nguyen HD, Wang X, and Bielinsky AK. Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair. Cell Cycle. 13(11):1737-48. 

Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L. PRP19 Transforms into a Sensor of RPA-ssDNA After DNA Damage and Drives ATR Activation Via a Ubiquitin-Mediated Circuitry. Molecular Cell. 53(2):235-46. 

2013

 

Nguyen HD, Becker J, Thu, YM, Costanzo M, Koch EN, Smith S, Myung KJ, Myers CL, Boone C, and Bielinsky AK. Unligated Okazaki Fragments Induce PCNA ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression. PLoS ONE.8(6):e66379. 

Shiotani B, Nguyen HD, Håkansson P, Maréchal A, Ho CK, Tse A, Tahara H, and Zou L. Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1. Cell Reports.3(5):1651-62. 

2010

 

Das-Bradoo S*, Nguyen HD*, and Bielinsky AK. Damage-specific modification of PCNA. Cell Cycle.9(18):3674-9 (*co-first author). 

Nguyen, HD and Bielinsky, AK. HMD2 ERKs PCNA. Journal of Cell Biology. (190):487-489. 

Das-Bradoo S*, Nguyen HD*, Wood JL*, Ricke RM, Haworth JC, and Bielinsky AK. Defects in DNA Ligase I Trigger PCNA Ubiquitylation at Lys 107. Nature Cell Biology. 12(1):74-9 (*co-first author).