We use multi-disciplinary approaches to elucidate cellular mechanisms of genome integrity maintenance and its impact on cancers.
Dr Hai Dang Nguyen
Principle Investigator, Dept. of Pharmacology
Dr. Nguyen is a Molecular Oncologist focusing on determining mechanisms and therapeutic strategies for Myelodysplastic syndrome and Acute Myeloid Leukemia patients harboring RNA splicing factor gene mutations. He is also a part of a multidisciplinary team in the functional genomics of solid tumors, launched by the Medical School and the Masonic Cancer Center to develop new technologies and models for understanding cancer heterogeneity. He received his B.A. degree from The College of Wooster, Ohio and Ph.D. degree from University of Minnesota in the laboratory of Dr. Anja-Katrin Bielinsky. He completed his postdoctoral research training in Dr. Lee Zou’s laboratory at Harvard Medical School and Massachusetts General Hospital Cancer Center.
EvansMDS Young Investigator - Edward P. Evans Foundation (2019-2022)
UMN CTSI pre-K Scholar (2020-2021)
American Society of Hematology Scholar - ASH Foundation (2021-2024)
UMN CTSI KL2 Scholar (2021-2024)
The Dang laboratory is currently developing small molecule probes, biochemical, cell biological and genetic approaches to investigate the underlying mechanisms of sensing and resolving R-loops in different cancers. Results obtained from these researches will provide molecular insight for the development of new targeted cancer therapeutic approaches.
